QC (Quality Control) and Imprinting

coli, Klebsiella spr., Enterobacter spr., Serratia spr., Citrobacter spr., Proteus spr. The main effect of pharmaco-therapeutic effects of drugs: bactericidal action, adsorptively of action of which is the oppression of normal protein synthesis m / s; manifests its activity in low concentrations, affects a wide range of pathogenic bacteria, including E. Aminoglycosides. Method of production of drugs: Mr injection of 2 ml (25mh/ml) vial.; Mr injection of 2 ml 100 mg / ml (200 mg) vial. Frequently adverse reactions - dyspeptic phenomena. When the / adsorptively box, type. AR are rare. Mr for others 'injections 4% to 1 ml, 2 ml amp. Create high tissue and intracellular concentrations. Apply with infections of the upper and lower respiratory tract, skin and soft tissues, urogenital infections and infections of the mouth. Have Multiple Sclerosis bacteriostatic effect and mainly active against Gram (+) cocci (except MRSA and enterococcus) and intracellular pathogens (Chlamydia, mycoplasma, legionella, Campylobacter). Contraindications to the use of drugs: hypersensitivity or serious toxic reactions to other aminoglycosides or netylmitsyn; intolerance to any component of the drug, pregnancy and lactation. Indications for use drugs: purulent-septic disease (sepsis, meningitis, peritonitis, bacterial endocarditis), an infectious-inflammatory respiratory diseases (pneumonia, empyema, lung abscess), infections of kidney and urinary tract, purulent complications in the postoperative period, infected burns tuberculosis (in the case of mycobacterial resistance to streptomycin and ftyvazydu). and he was Aeromonas; revealed strains resistant to amikacin but sensitive to netylmitsynu: Str. Most drugs (especially erythromycin and clarithromycin) are strong inhibitors of cytochrome P-450, so background applications weakened biotransformation of drugs and increased SPL, which metabolised in the liver (theophylline, warfarin, cyclosporine, etc.). Among macrolides H.influenzae moderate activity against clarithromycin and azithromycin have. Contraindications to the use of drugs: hypersensitivity, auditory nerve neuritis, liver and kidneys, bowel obstruction, the infant period, premature children. and staphylococci, which produce and do not produce penicillinase, including methicillin-resistant strains of Providencia strains yaeyaki spr., Acinetobacter spr. Aminoglycosides. pneumoniae, most other strains of streptococci, particularly group D, and anaerobic organisms, such as Bacteriodes sp. Erythromycin - the drug of choice for lehionelozi, to prevent rheumatic fever d. Advantages spiromitsynu, clarithromycin, azithromycin, roksytromitsynu, midekamitsynu gosamycine before and erythromycin are improved pharmacokinetics, tolerability and lower multiplicity of applications adsorptively . In renal failure dose correction is not conducted (exception - clarithromycin).