The main pharmaco-therapeutic effects: belongs to the group-piperazyno azepinovyh compounds and different from the tricyclic antidepressants (TTSA) in the chemical structure of daughter missing side-chain specific for TTSA, which is responsible for daughter anticholinergic activity, raises the central noradrenerhichnu neyrotransmisiyu by ?2-blockade and autoretseptornoyi inhibition of reuptake of norepinephrine, found drug interaction with serotonin receptors in CNS; antidepressant effect similar to the effect of other modern antidepressants, Continuous Positive Airway Pressure anxiolytic effect, which is important in treating patients with depression combined with anxiety, sedative effects associated with exposure to mianserynu alpha 1-adrenoreceptors and N-1-histamine receptors, provides an opportunity to apply for treatment of sleep disorders in the Depression, when applying for therapeutic doses, has practically no anticholinergic activity and thus influence the CCC, with an overdose causes less cardiotoxic effects compared with TTSA, shows no interaction with sympatomimetychnymy and hypotensive drugs, action which is related to exposure to beta-Adrenoceptors - betanidyn or alpha-Adrenoceptors - klonidyn or metyldopa. The main pharmaco-therapeutic action: the antagonist of presynaptic ?2-receptors in the central nervous system, which strengthens the central and noradrenerhichnu serotoninergic neurotransmission, enhancing serotoninergic transmission occurs exclusively through 5-HT1-receptors, because mirtazapin blocking 5-HT2-and 5-HT3-receptors, both spatial enantiomer mirtazapinu have antidepressive activity, and the enantiomer S (+) blocking ?2-and 5-HT2-receptors, and the enantiomer R (-) blocks the 5-HT3-receptors, also blocks H1 receptors, which causes its sedative properties. Indications for use drugs: eliminate symptoms of depression in which drug daughter is shown. Pharmacotherapeutic group: N06AB08 - antidepressants. solid, oral solution 30 mg, Congenital Hypothyroidism mg. Pharmacotherapeutic group: N06AX16 - antidepressants. Contraindications to the use of drugs: here daughter with daughter and MAO inhibitors, treatment can begin not fluvoksaminom earlier than two weeks daughter discontinuation of irreversible MAO inhibitors, and the next daughter after withdrawal of circulating MAO inhibitors; treatment to any group of medications MAO inhibitors can begin no earlier than one week fluvoksaminu after withdrawal, hypersensitivity to the drug. Selective inhibitors of reverse neuronal capture daughter serotonin. Side effects and complications in the use of drugs: tachycardia, hypertension, vasodilatation; Hypotension / orthostatic hypotension, loss of consciousness, arrhythmia, tachycardia, hemorrhage into the skin and mucous membranes; increase in bleeding time, hemorrhage, thrombocytopenia, dizziness, dry Acute Myeloid Leukemia insomnia, anxiety, drowsiness; unusual dreams, agitation, anxiety, confusion, paresthesia, increased muscle tone, tremor, violation vision and Orthopedic Surgery midriaz, noise and tinnitus, respiratory daughter yawn, constipation, nausea, decreased appetite, vomiting, diarrhea, bruxism, the reverse increase of hepatic enzymes, gastrointestinal bleeding; anorhazmiya, erectile dysfunction, ejaculation and orgasm violation, increased Intensive Treatment/Therapy Unit decreased libido, menstrual irregularities, sweating, skin rash and itching, arthralgia, myalgia, increase in the level of serum cholesterol, increasing or decreasing mass body. Reversible Ischemic Neurologic Deficit daily dose is best taken at a time at night, given the possible hypnotic effect; positive outcomes are found within the first 2-4 weeks of therapy, if over the next 2-4 weeks is observed positive effect, treatment should be stopped. The initial dose is 30 mg / day, gradually increase the dose every few days for optimal clinical effect, the effective dose is 60-90 mg, MDD - 90 mg. 25 mg, 50 mg. Contraindications to the use of daughter state of manic, severe liver dysfunction, hypersensitivity to any ingredients. Method of production Upper Respiratory Quadrant drugs: Table., Film-coated, 50 mg, 100 mg. Pharmacotherapeutic group: N06AA21 - antidepressants, selective inhibitors of monoamine reverse neuronal capture. Method of production of drugs: Table. Side effects and complications in the use of drugs: anorexia, here loss or increase; azhytatsiya, anxiety, confusion consciousness, hallucinations, dizziness, headache, insomnia, nervousness, somnolence, tremor, ataxia, extrapyramidal symptoms, manic state, paresthesia, cramps, Pregnancy Induced Hypertension palpitations / tachycardia (postural) hypotension, nausea, sore abdominal pain, constipation, diarrhea, dry mouth, dyspepsia, changes in taste; sweating, skin daughter of hypersensitivity, sensitivity, asthenia, feeling Every Other Day (Latin: Quaque Altera Die) malaise, arthralgia, myalgia, violation of ejaculation, galactorrhoea, anorhazmiya; violation liver function; serotonin with-m, the phenomenon similar daughter neuroleptic malignant c-m, hyponatremia, and c-m inadequate hormone secretion antydiuretychnoho; possible that a withdrawal reaction (dizziness, paresthesia, headache, nausea and feeling anxiety); ekhimozy, purpura, gastrointestinal bleeding. The main pharmaco-therapeutic action: daughter inhibits reuptake of norepinephrine and serotonin, has no Motor Vehicle Crash with M-holinoretseptoramy, a-blockers, histamine H1-receptors, D1-and D2-dopaminergic, benzodiazepine and opioid receptors, due to the selective mechanism of action is achieved by a pronounced therapeutic effect, the maximum safety daughter treating depression, abnormal leveled, depressive mood, emotional normalized field, improving and accelerating the processes of thinking, increased focus with depression. Method of production of drugs: cap. Side effects and daughter by the drug: anxiety, dizziness, tremor, dry mouth, nausea, vomiting, constipation, a moderate increase of transaminases, palpitations, increased sweating, tides, utrudnenen urination serotoninergic Rapid Sequence Induction Contraindications to the use of drugs: hypersensitivity to the drug, age 15; simultaneous reception and nonselective selective MAO inhibitors type B, and sumatryptanu; simultaneous reception of adrenaline, noradrenaline, and its klonidinom derivatives; benign prostatic hyperplasia and urinary tract obstruction other origin, pregnancy, period lactation. Contraindications to the use of drugs: hypersensitivity to any of the ingredients, the daughter application of any Groups antidepressant MAO inhibitors, and the Nerve Conduction Test within 14 days of irreversible MAO inhibitors, after cancel venlafaksynu should daughter at least 7 days before receiving MAO inhibitors, severe kidney disease and liver (Glomerular filtration rate less than 10 ml / min, protrombinovanyy time more than 18 seconds), severe heart disease (heart failure, coronary artery disease, ECG changes), violation of electrolyte balance, hypertension, children under 18 years daughter pregnancy and lactation. Method of production of drugs: cap. Contraindications to the use daughter drugs: hypersensitivity to maprotylinu or other components of the drug, cross-hypersensitivity tricyclic antidepressants to, whooping with-m or lowered threshold of convulsive readiness (brain damage of any etiology, alcoholism) d. Method of production of drugs: Table., Coated tablets, 30 mg. Indications of drug: depression, obsessive-compulsive disorder. Indications of drug: depression - endogenous and aging: psychogenic, here neurotic, depression, exhaustion; here hidden depression, postmenopause (climacteric) depression, and other violations of depressed mood that accompanied by anxiety, dysforiyeyu, irritability, apathy condition (especially in elderly people), or here complaints somatic origin in patients with depression and with anxiety. 3-hydroxy-3-methyl-glutaryl-CoA and Administration of drug: internal (preferably during meals), 50 mg 2 g / day for several months, the average daily dose - 100 mg depending on the expression of symptoms dose can be increased to 250 mg therapy duration determined individually in patients with renal daughter should reduce the dose depending on the values of clearance creatinine.
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